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tecovirimat will increase the degree or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Watch for adverse effects if coadministered with delicate substrates of these enzymes.Belzutifan can be a CYP2C19 substrate. Coadministration with CYP2C19 inhi